Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.
نویسنده
چکیده
The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for the striking heterogeneity of malignant cells within a tumor and for the rapidity by which cancers become resistant to therapy. Cancer Res; 76(8); 2057-9. ©2016 AACRSee related article by Loeb et al. Cancer Res. 1974;34:2311-21.
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ورودعنوان ژورنال:
- Cancer research
دوره 76 8 شماره
صفحات -
تاریخ انتشار 2016